Roles of First Ladies

Roles of the First Lady Kenya Stanford Ashford University HIS 204 American History Since 1865 Instructor: Tara Ross November 15, 2010 Abstract The roles of the First Lady can vary. Several of the authors describes that some of the First Lady’s roles can be from writing invitations , creating an policy, sharing ideas about political rights, to coming up with health care reform. This essay contains some of the old traditional roles that the First Lady was required to do in the 18th century and how it changes over time. Also, it explains how each century First Lady goes about performing her duties.Roles of the First Lady The roles of the First Lady are really undetermined because it changes due to their interest and the timeframe that they were in. Traditional roles of the First lady The duties of the First Lady vary from time to time. During the 18th century, the traditional roles of the First Lady were being a hostess for our country. White House. Gov states, â€Å"The Preside nt and the First Lady’s job responsibilities are to entertain both national and international guest that were arriving and staying at the White House (White House. gov). It also goes on stating that the reason for hosting the event was to strengthen any existing ties, to stage for new relationships, to establish new partnerships, or just to extend the hospitality of the White House as the â€Å" home â€Å" of our nation leader and every First lady were responsible for writing every single invitation by hand (FirstLady. org). 18th Century First Ladies: Martha Washington and Abigail Adams Martha Washington was a well-respected and very kind-hearted to all that knew her. However, Martha did not enjoy her roles as being the First Lady.According to the article, she statedâ€Å" I think I am more like a state prisoner than anything else, there is certain bounds set for me which I must not depart from any many younger and gayer women would be extremely pleased in her place; she would be much rather be at home (White House. Gov). † Just by reading the article on her, it gives me the idea that she was very private about her life with outsiders and she always held her head up. During her time she was called â€Å"Lady Washington. † She had gotten that name during the Revolutionary War era (America. ov). During the war era, Martha Washington was placed into a winter encampment that was the most comfortable to live in (Berkin, Carol). During the war, she and the other general wives served as hostess. The purpose was to lift everyone spirits and giving every solider a reason on what they were fighting for (Berkin, Carol. ) After Martha had moved to the White House, she found out that she was also responsible for managing the presidential household and supervising the domestic affairs at Mount Vernon from a distance (MarthaWashington. us).However, her successor Abigail Adams was a very interesting woman of her time. People viewed her as a very patrio t woman. Abigail’s letter talked about current politics and how she expressed her opinions. During the time of when the famous â€Å"shots heard around the world† started, Abigail was writing John letters to express her concern and her longing to be with him. According to Carol Berkin, ‘Soon I will be in continual arms. Rumors have spread that the British has spread. We know not what a day will bring forth, nor what distress one hour may throw us into (Berkin, Carol). During her husband’s presidential, she would write letters that was expressing her ideas about women’s right. For example, one of her famous letters was when she wrote John telling him to remember the ladies when it came down to the new law (New World Encyclopedia). Basically, she was trying to gives the women more rights that they were entitled to but during the American Revolution that was proving to be was very impossible task. According to New World Encyclopedia, â€Å"Highly cons cious of her role as the president's wife, Abigail Adams saw her role largely as a hostess for the public and partisan symbol of the Federalist Party.Her entertainments were confined to a relatively small home in Philadelphia, turned into a hotel after the capital was moved from Philadelphia to Washington, D. C. (New World Encyclopedia). †. She also attempted to influence fashion, believing that the more revealing Napoleonic-style clothing then popular were too indecorous. Since presidential families were responsible for covering the costs of their entertainments and the Adamses were enduring financial difficulties at the time of his presidency, Abigail Adams's receptions were somewhat Spartan (New World Encyclopedia). 19th Century: Mary Lincoln and Ida McKinley Mary Lincoln was a woman who wanted the public to like her. She was getting to point where she was tired of the public talking about her fashion so she decides to do a makeover for herself and for the White House.At th e beginning through the end of the article, the author discusses how Mary Lincoln was very careless with money and how she would act out if she didn’t get her way (Lincoln White House. org). The Lincoln Institute only notes that Mrs. Mary Lincoln visited the wounded from the Civil War and remodeled the White House (Lincoln White House. rg). Ida McKinley was a very ill person who suffered from being epilepsy. Her conditions were affecting her and her husband job performance. According to Miller Center Public Affairs, â€Å"Although she occasionally appeared at state dinners and in receiving lines, her attendance at these functions was sporadic due to the unpredictability of her seizures (Miller Center, 2010). † It also goes on stating that the president had to ask the vice president’s wife to help her with her duties due to her being sick.Even though she was very sick, she manages to crochet bedroom room slippers for fundraisers and charities. After reading the a rticle, she proves that she was able to show her husband that she cared about how he felt about politics and that she would dedicate herself to it through the end. She was the first to have her spouse to reschedule everything around her instead of the President reschedule everything around him. 20th Century: Edith Roosevelt and Jacqueline Kennedy Following President McKinley’s assassination came about very sudden to Edith.So Edith had to fill in that position as First Lady. Not being a stranger to Washington and to the public, Edith was able to perform her job really well. Edith was very good at managing books and being able to keep up the home. But just like Martha Washington, she kept her life private from everybody including T. R’s extended family. According to the Theodore Roosevelt Association, â€Å"Under Edith's careful eye the White House collection of china and the portraits of First Ladies were begun.The task of restoring the house to its classic and simple federal style, inside and out, while accommodating a large family and executive branch of government for a growing nation came to the Roosevelt’s. First Lady Edith Roosevelt played the major role in overseeing the largest renovation of the White House into the stately and practical government center it is today (theodoreroosevelt. org). † Just like Martha Washington, Mary Lincoln, Edith Roosevelt, and Abigail Adams, the next First Lady named Jacqueline Kennedy tends to follow in some of their steps.Her first big role as First Lady was the historical restoration of the White House (JFK Presidential Library and Museum. ). The article stated that she created a White House Guide and authenticates the artwork. She also created the White House Historical society; posts White House curator, oversaw to creating a publication of a guidebook for the visitors, and finally established the White House Library and the Rose Garden (JFK Presidential Library and Museum. ).Later on, Jacq ueline Kennedy becomes a host for the television tour by CBS in 1962 (JFK Presidential Library and Museum. ). 21st Century: Laura Bush and Michelle Obama Unlike the other former First Lady, Laura Bush manages to go to the extremes with her duties as First Lady. According to National First Ladies Library, â€Å"Education has been the primary focus of Laura Bush's tenure as First Lady and the issue that has bound all the various efforts she has spearheaded.When she eventually was able to deliver testimony before the Senate Education Committee on January 23, 2002, Laura Bush called for higher teacher salaries and better training for Head Start and day care workers. In the nine month of her tenure introduced a National Book Festival in Washington, D. C. based on the model of the one she had created in Texas. Within two years, this festival had inspired the Russian First Lady Ludmilla Putin to host an October 1, 2003 book festival in her nation that Laura Bush attended in Moscow, along with several American authors (National First Ladies Library, 2010).She also went to Afghani to met the women and to hear how miserable their lives have been since the war, and she created a public-forum to help with the techniques to comfort children that were traumatized during and after 9/11(National First Ladies Library, 2010). Again, every First Lady’s ideas about how to perform her job is different just as Michelle Obama have stated. Michelle states that â€Å"This new administration doesn’t view service as separate from our national priorities, or in addition to our national priorities.We see it as the key to achieving our national priorities,† she continued. â€Å"We believe that the only way to build that new foundation for our economy is to establish a new role for service in this country (America. Gov). † The article continues to talks about how Michelle talks about how you can volunteer to make differences. Michelle’s second role as Fir st Lady was to reconstruct a playground and packed over 15,000 backpacks for the children of America’s service members to take with them to summer camp (America. Gov).White House. Gov states that as First Lady, Mrs. Obama looks forward to continuing her work on the issues close to her heart — supporting military families, helping working women balance career and family,   encouraging national service, promoting the arts and arts education, and fostering healthy eating and healthy living for children and families across the country (America. Gov) As I stated earlier, every First Lady’s role is undetermined because it changes due to their interest and the timeframe that they were in.Every First Lady has their ways on how they would like to do things. Some of them may not have a lot of experiences when it comes to politics and some may. Whether it is making sockets or reconstructing a playground, these women are using their talents in helping others. Like Michell e stated, â€Å"â€Å"There’s a feeling that you get when you help someone achieve their goals: the fulfillment of putting your faith into action and feeling that you’re a part of something that’s bigger than yourself and doing your part for the greater good.Bibliography America. Gov. (2009, June 29). Retrieved from America. Gov-Engaging the world: michelle Obama defines own Rosle as First Lady: http://www. america. gov/st/usg-english/2009/June/20090629092010degrebsginek0. 475445. html Berkin, C. (2005, February 01). Revolutionary Mothers: Women in the Struggle for Americans' Independence. United States, United States: Alfred A. Knopf Incorporated. Institute, T. L. (2010). Mr. Linclon's White

Geneogram

THE COMMON PATTERNS THAT I SAW ON MY GENEOGRAM AND HOW IT AFFECT WHO I AM TODAY Upon making and completing my Geneogram, the first thing that I got to realize is that I am really lucky with my family. We might not have a lot of professionals just like other families but no one in our family, whether mother or father side has any mental issues or any addictions to anything. Also, there are no bitter misunderstanding within our family that might have resulted to any conflicts.Another common pattern that I saw is the common profession in our family. It is either engineering or nursing. This might explain as to why I chose engineering as a profession. It is visible that It is the common profession being practiced in our family. Another significant pattern that is visible is the number of children each of my Tito/Tita have. No one from any of my Tito/Tita has a number of children greater than three. This might explain why my mother and father only had two children of their own.Also, anoth er pattern that is visible is the age in which my cousins had children. My geneogram results shows that no one from my cousins became a parent before the reach 25. This might also in a way explain as to why I still don’t have children of my own today. THINGS TO HEAL / CHANGE IN MY GENEOGRAM PATTERNS Even though my geneogram is quite a normal, good geneogram of a normal family, there is one area of improvement that I saw. There might be little areas to heal or I wanted to change.That area is that we do not have a pattern our family that has a leadership or entrepreneurial background. Most of my family’s pattern shows that most of us became professionals. That might not be a bad thing for others, but it might be for me because I wanted to have my own business someday and if I were to look at my family’s geneogram there is no significant pattern that shows me that there is a leadership or entrepreneurial pattern. So I cannot get the said skill anywhere within my fa mily.But to clear things up, I love my family, I don’t want to change anything and I don’t want to give it up for anything in the world but just of academics sake, if I were to choose an area for improvement, I think that will be it. HOW CAN MY ANSWERS ABOVE HELP ME BECOME A LEADER IN MY WORKPLACE? Now that I have seen that what are the patterns and areas of improvement from my geneogram, more specifically the family members that does not have leadership skills. This might explain why I also lack leadership qualities in my office.I was offered on many occasions, from my previous and present work, to have an opportunity to be promoted and handle people. But I turn down those opportunities because deep in my heart I think that I am afraid to take the lead because I don’t have the said background from my family and does not feel comfortable leading people. And upon doing this geneogram, I got to realize that yeah, I am afraid to lead people because no one in my fam ily taught me that skill. And I think for me is the greatest area of improvement for myself and my career.

An Evaluation of the Relevance and Utility of Lean Manufacturing Approach to the Pharmaceutical Supply Chain

Introduction This critical analysis report is aimed at evaluating the relevance and utility of the Lean manufacturing approach to the pharmaceutical supply chain. It covers the principles and application of Lean manufacturing in supply chain management; its potential advantages to the management of quality and efficiency in pharmaceutical industry; and whether Lean is appropriate for the pharmaceutical supply chain. Novartis and Lundbeck case studies are used to describe how the Lean approach is applied to pharmaceutical industry. Principles of Lean manufacturing in supply chain management Lean thinking is a concept that describes a production philosophy aiming for progressive elimination of waste whist safeguarding the critical value (Ende 2011). According to (Sople 2012: 113), the principles of Lean manufacturing are â€Å"customer value, value stream analysis, demand pull, continuous flow, and waste elimination.† The purpose of a Lean supply chain network is to bring the lowest cost in differential customer value, which can be met through collaborative priorities in demand, real-time information on markets, and logistics delivery efficiencies, to name a few. The concept of networks of supply chain partners suggests that the success of companies is through their constant origination from new networks of supply chain partners in order to meet certain objectives. As a general rule, these constantly developing networks can act in response to the dynamic characteristic of customer demand (Sople 2012). The manufacturing function must not be the only domain to whic h Lean principles must be applied. Rather, it must also be applied across organisations in the supply chain to decrease the wastes usually associated with supply chain operations. The full benefit of Lean manufacturing and supply chain management necessitates that the scope of Lean implementations must go beyond a single function and must be structured as a part of managing relationships with customers and suppliers (Lambert 2008). It may therefore be analysed that with the adoption of Lean techniques, the management is tasked to align corporate activities with Lean manufacturing in supply chain management across organisational functions. Lean thinking also allows the organisation to direct business relationships with customers and suppliers. Application of Lean Principles Lean thinking is apparently applicable to pharmaceutical development and manufacturing (Wigglesworth and Wood, 2012). Lambert (2008) states that whilst the various material flows as well as flows of goods and information are the focus of Lean supply chain operations, Lean application to the management of supply chains is further from the physical flows of inventory. It also takes account of the entirety of the business relationship amongst firms. When a firm applies Lean manufacturing concepts to its supply chain management, it begins to focus on value drivers; revenue development; asset efficiency, and reductions in cost, inventory, and working capital. All of these are apparently beneficial to an organisation. Applying Lean thinking to supply chain management is very likely since both of them share commonalities, such as long-term perspectives, value and customer creation; systems view; and structured business relationships;amongst others (Lambert 2008). These commonalities indicate how much Lean thinking and supply chain management lend to each other. Based on this, one can conclude that Lean approaches are aligned to supply chain management and that the two are generally not in contrast with each other. Potential advantages of Lean approach to managing quality and efficiency in the pharmaceutical industry One of the potential advantages of Lean approach in the pharmaceutical industry is the reduction of cost of goods in pharmaceutical development and manufacturing. The implementation of Lean thinking can be carried out by developing workflows and infrastructures to reduce inventories (Ende 2011), which are in fact a target of quality and efficiency efforts within pharmaceutical companies. The concept of continuous manufacturing in pharmaceutical companies deals with the challenge of overproduction, which leads to surplus inventory and longer cycle teams. These are the focus of efficiency on which pharmaceutical companies must be engaged. Its significance is seen in the fact that excess inventory is considered the greatest waste because it brings upon itself certain costs related to the management, storage, and transport of inventories adding to the waste (Schneider 2010). Therefore, when Lean techniques are used, such wastes are reduced, if not totally eliminated within the pharmaceu tical firm. Novartis and H. Lundbeck case studies Novartis is one of the world’s largest pharmaceutical firms (Abreau 2013). The upstream part of its supply chain indicates flow of information and full visibility. Novartis uses product-to-demand technique based on demand, whereby its daily variable demand stream is integrated to production (AMR Research 2006). Between its levels of supply chain are limited visibility and flow of information (Abreau 2013). Despite being ranked number 2 behind Pfizer in cost of goods sold in 2006, Novartis decided to take on Lean principles and become the â€Å"Toyota of pharmaceuticals.† Using Lean principles, the company is focused on reducing its cycle time to 70 per cent and reducing spending by 40 per cent, as well as pursuing continuous manufacturing with raw materials going in one end of the chain and finished products coming out the other (AMR Research 2007). Along with this is the reengineering of every process and role, leveraging information technology, and setting up process-oriented teams in the absence of first-line supervisors so that personnel would report directly to one team leader (Shanley 2004). Here, one can see the application of Lean techniques to Novartis’ supply chain, thereby helping the company to improve its internal processes and eliminate waste. Lundbeck, on the other hand, is an international pharmaceutical firm that began its Lean adoption in 2005. The company went through certain phases in its Lean adoption, such as building consensus in the management group and running a range of Lean events and building a culture around these events. In the first phase, Lundbeck implemented 40 Lean events assisted by external experts, followed by 70 to 80 Lean events each year, with all personnel in the supply chain being involved (Simpler Consulting 2010). Through its adoption of Lean principles in its supply chain, the company was able to cut costs by 25 per cent. Workflow analysis within the organisation is also aided by video cameras, which leads to further improvements. Part of its Lean techniques adoption is the use of large bags instead of small box packaging, which reduced production delays from four hours to only an hour (Miller 2012). Is Lean appropriate to the pharmaceutical supply chain? Yes, Lean techniques are appropriate to the pharmaceutical supply chain. Despite Lean thinking’s origination from Toyota manufacturing, its adoption is still suitable to the pharmaceutical industry. In fact, its applicability is seen in the number of pharmaceutical companies that continue to adopt Lean manufacturing techniques. Although many of these techniques cannot be taken on to the more complex pharmaceutical manufacturing plants, their adoption mirrors the pursuit of increased optimisation (Shanley 200). Boyer and Verma (2010) surmise that whilst the original focus of developing Lean thinking is the manufacture of automobiles, it can still be applied to other industries. This is because Lean approach is more than a set of techniques but is a mindset for all personnel and managers who are focused on waste elimination and reduction of variability in the entirety of the business process. The advantage of Lean’s adoption in the pharmaceutical industry is the ability of pharmaceutical companies to experience logical rhythm through the supply chain. With the Lean enterprise, adaptive supply chain is carried out, causing the whole organisation to possess real-time process visualisation (Hafeli 2006). Argument for agility in the pharmaceutical supply chain Pharmaceutical companies are inclined to be bureaucratic, which results in several wastes in internal processes. With the application of Lean principles, pharmaceutical companies are able to strengthen their relative agility (Radeka 2013). This would mean that despite the relative limitation of the application of Lean principles in the pharmaceutical supply chain as pointed by WCI Consulting Limited (2011), the result is still improved agility in the supply chain. Apparently, the need for agility in supply chain management is founded on decreasing product life cycles and demand patterns of increasingly volatile markets. Sweeney (2009) points out that Lean is not enough, that agility in supply chain is required because of emphasis on speed, with time being a major competitive weapon. This argument is reasonable given the rapidly changing market in which pharmaceutical companies operate. However, as emphasised above, Lean thinking is also applicable to the pharmaceutical industry. An argument arising about the adoption of Lean thinking in the pharmaceutical industry is the risk that goes with it. Such adoption is said to put the supply chain to increased vulnerability to disruptions and unpredictable events due to lack of slack on which to withdraw. With Lean techniques making the supply chain vulnerable, a question that may come up is whether this would mean Lean is not suitable at all. The answer is pharmaceutical companies can apply Lean techniques to cut costs and adopt agility in order to obtain supply chain resilience, as pointed out by WCI Consulting Limited (2011). Conclusion This paper provides a critical analysis of the relevance and utility of Lean techniques in the pharmaceutical supply chain. Lean thinking allows the elimination of wastes and cost reduction in pharmaceutical companies. Lean supply chain considers the entirety of the business relationship amongst firms. Reduced costs of goods and reduced inventories are the potential advantages of Lean approach in the pharmaceutical industry. Novartis and Lundbeck case studies provide an example where Lean techniques and supply chain management become integrated. Despite the effectiveness of agility in supply chain management, Lean cannot be set aside as a valuable tool. References Abreau, P. E. M. (2013) An ANP Model to Support Decision-Making in a Portuguese Pharmaceutical Supply Chain. Reterived on March 22, 2014 from http://run.unl.pt/bitstream/10362/10724/1/Abreu_2013.pdf AMR Research (2006) Supply Chain Saves the World. US: AMR Research, Inc. AMR Research (2007) Risk!: Navigating an Uncertain World. US: AMR Research Inc. Boyer, K. and Verma, R. (2010) Operations and Supply Chain Management for the 21st Century. First Edition. Mason, OH: South-Western, Cengage Learning. Ende, D. J. (2011) Chemical Engineering in the Pharmaceutical Industry: R&D to Manufacturing. New Jersey: John Wiley & Sons. Hafeli, R. (2006) Enabling Lean and Compliant Manufacturing at Novartis with SAP. Denver: SAP Adaptive Manufacturing Summit, September 28. Lambert, D. M. (2008) Supply Chain Management: Processes, Partnerships, Performance. Sarasota, FL: Supply Chain Management Institute. Miller, G. (2012) Lean Earns Lundbeck Big Prize, Cost Cuts. Retrieved on March 22, 2014 from http://www.fiercepharmamanufacturing.com/story/lean-earns-lundbeck-big-prize-cost-cuts/2012-01-18 Radeka, K. (2013) The Mastery of Innovation: A Field Guide to Lean Product Development. NW: CRC Press. Schneider, O. (2010) Adding Enterprise Value: Mitigating Investment Decision Risks by Assessing the Economic Value of Supply Chain Initiatives. Zurich: vdf Hochshulverlag AG Shanley, A. (2004) Novartis Goes Lean. Retrieved on March 22, 2014 from http://www.pharmamanufacturing.com/articles/2004/111/ Simpler Consulting (2010) Lean Management of the Pharmaceutical Sector Brings Increased Efficiency and Improved Quality While Increasing Profits. Retrieved on March 22, 2014 from http://www.simpler.com/success-stories/Lundbeck_Case-Study.pdf Sople, V. V. (2012) Supply Chain Management: Text and Cases. New Delhi: Dorling Kindersley Pvt. Ltd. Sweeney, E. (2009) Lean, Agile and Resilient Pharmaceutical Supply Chains: Jargon or ActionIrish Pharmachem Buyers Guide (September), 38-39. WCI Consulting Limited (2011) Keeping the Supply Chain Agile. Retrieved on March 22, 2014 from http://www.wcigroup.com/Nostrapharmus/Keeping%20the%20supply%20chain%20agile.pdf Wigglesworth, M. and Wood, T. (2012) Management of Chemical and Biological Samples for Screening Applications. Germany: Wiley-VCH Verlag & Co.

Heart Disease and Stroke Screening Essay Example | Topics and Well Written Essays - 250 words

Heart Disease and Stroke Screening - Essay Example (Sudano et al., 2010) An example of Screening is where you measure the CRP (C-reactive protein) levels In one’s blood. As a role of the human resistance system, the CRP levels become elevated due to infection. This test is crucial as it helps to determine the risk of one getting stroke or heart diseases. An institute (Lankenau Hospital) in Philadelphia conducts heart illness and stroke with carotid artery ultrasound, ankle brachial index (ABI), abdominal aortic aneurysm (AAA) screening, peak systolic velocity (PSV), heart rhythm electrocardiogram (EKG), mass body index and pressure check in blood at a cost of $50 (Mainlinehealth.org, 2015) The screening tests as per now are very effective and efficient, and I could recommend that everyone does screening test regularly as it very healthy, From study assessment of screening affirms by demonstrating that that individuals with higher cardiovascular illness danger components that did the tests  changed their lifestyle i.e, reduced their cholesterol intake and start to excise. Particular dropout (specific whittling down) inclinations are also affirmed , whereby individuals with more way of life danger components (smoking, higher liquor utilization, overweight) tend to return for subsequent arrangements and follow-up of their conditions. In the long run, regular screening checks help save lives (Sudano et al., 2010) In my opinion there is no need for changes in the screening process as they have and are still providing valid results.Changes may only be nessecessarly in the nearer future when the existing screening test are declared void.The screening programs should be made free since the have a vast range of positive impacts Sudano, I., Flammer, A. J., Periat, D., Enseleit, F., Hermann, M., Wolfrum, M., Ruschitzka, F. (2010). Acetaminophen Increases Blood Pressure in Patients With Coronary Artery Disease. Circulation.

For Rousseau, man is born free and everywhere he is in chains. Do you Essay

For Rousseau, man is born free and everywhere he is in chains. Do you agree with this assessment Discuss with reference to - Essay Example The first man who accustomed himself as an owner of a land had first brought the idea of tyranny and oppression in society. Prior to the idea, that society had succumbed to ownership; there have been less crime and hardship, and sorrow was out of sight. However, when man succeeded in the act of ownership with it began the invisible chain attached to every human being born. Furthermore, man emerged when he was first to think of himself, provide for his own needs, and was ignorant of his ability to own properties and be above with others. Nonetheless, the time came that he felt the difficulty to do things all by himself and do against the natural circumstances. The differing tides of the time, the changes of the environmental conditions, and other natural and unexpected circumstances had brought man to a point where he considered these as no longer natural. It became a significant source of hardship for him. In order to survive the hindrances, man needed to learn to be above other spec ies. He needed to eat; therefore, he hunted down other species, which had brought him to think that he is above them. This superiority brought man to boast and take pride of himself. As a result, the solitary man had evolved into seeing his likeness to other human beings. His ability to incorporate himself with others and his ability to be part of the lives of others came to being naturally, and at first, language was not needed in order to interact. Jean Jacques Rousseau added that, in line with man’s ability to interact and be above other species, he was able to evolve into a person who has learned the usage of tools. These primitive tools brought man to build huts. In these huts were families, considered as the smallest part of a society, which begun to hold property on where their huts stood. The families, which composed of a man and a woman, lived under one roof and were able to bear children. After the establishment of the first society, man became more convenient on hi s way of living. However, his needs accumulated and losing these needs and not sufficiently having these needs made him unhappy. Moreover, language emerged during the time when man experienced natural catastrophes. This had caused man to be able to communicate in order to combat and surpass these instances. Furthermore, in the emergence of language, man became more civilized and eventually formed nations. Along with this, the love within families heightened in the light of ideas and preferences of the nations. Negative ideologies also came about which also brought walls between the differences of the different group of people. People were grouped in accordance to the songs they were singing and to the steps they were dancing. A wall between people was established by identifying one as different from the others. This then caused inequality, and vices became real in the realm of societies. This had brought man to believe that, by nature, he is unjust, disrespectful and that politics m ust emerge to be able to maintain peace and order. However, this has been wrongly inferred because man, at its natural state is gentle. Moreover, the earliest society depicted happiness among its people; however, progress eventually brought inequality. Freedom was felt by every individual; however, the inevitable chains of slavery and captivity were brought to existence

Cost Effectiveness for Smoking Cessation Assignment

Cost Effectiveness for Smoking Cessation - Assignment Example This relatively new (it was invented in China, 2003) device fully reproduces the process of smoking. Moreover, it is not harmful and helps to give up a bad habit. Although smoking cessation by means of electronic cigarettes seems to be a good method, a lot of people do not want to try this. It happens because there is a myth that these cigarettes are too expensive and it is better to buy something else in this case. This statement does not face real situation. That is why it is necessary to investigate the cost effectiveness and peculiarities of electronic cigarettes. The research concerning the problem under analysis was conducted by means of the following methods: 1) An anonymous Internet-based and cross-sectional survey. It took place among the first-time purchasers of electronic cigarettes. 2) Interviewing of people who smoke 3) The systematization and analysis of the information received in the process of investigation. 4) Anonymous interrogation. As for the results of my resear ch, there happened to be more men than women in the study. Thus, there were 71.5 percent of men and 28.5 percent of women. The majority of people asked had been smoking for six or even more years. The first group composed approximately 81.1 percent. It should be noted that a lot of people participating in the investigation tried to give up smoking several times (64.7 percent), but nothing helped them and there seemed to be no way out of this situation. Below are the details concerning demographic information, smoking characteristics and reduction of tobacco use after electronic cigarette use. Table 1. Demographic Information Variable N (%) Gender of the participants Male 153 (71.5) Female 61 (28.5) Age of the participants 19-24 41 (19.1) 24-44 114 (53) 45-64 48 (22.2) Over than 65 12 (5.7) Table 2. Smoking Characteristics Variable N (%) Years smoked or smoking history Less than 5 32 (14.8) 5-15 77 (35.5) 16-30 67 (30.9) More than 30 41 (18.8) The number of previous attempts to quit 0 16 (7.8) 1-2 59 (27.3) 3-5 90 (42) More than 5 59 (22.8) Table 3. Cessation or Reduction of Tobacco Use after Electronic Cigarettes use Variable N (%) Reported reducing nicotine use Yes 106 (49.2) No 109 (51) Reduced amount of tobacco cigarettes per day after electronic cigarette use Yes 143 (66.7) No 71 (33.1) Quit or abstained for a period of time Yes 105 (48.9) No 109 (52) It is seen from the tables listed above that more than the half of the participants (about two thirds) noticed positive results after the use of electronic cigarettes. They noted that the desire to smoke was decreased by means of this device. These people started smoking nicotine cigarettes more rarely than usual. Approximately the half of the participants stated that they had given up smoking for a short period of time after buying electronic cigarettes. It should be stressed that more than thirty percent of respondents were not smoking at the six-month point. The relation of electronic cigarettes to six-mon th smoking status is demonstrated in the table below. Table 4. The Relation of Electronic Cigarettes to Six-Month Smoking Status Use Pattern % of not smoking respondents Total. Smoking status at six-month point (n=217) 31 (24.8, 37.3) The number of times applied per day No current electronic cigarette dose (n=98) 26.7 (17.9, 35.7) Less than 5(n=50) 28.0 (15.4, 40.6) 5-10 (n=31) 35.5 (18.3, 52.7) 11-15 (n=16) 31.3 (6.2, 60.4) 16-20 (n=12) 33.2 (6.3, 60.4) More than 20 (n=10) 70.1

Spanish immigrantion to United States from 1800's to the 1865 Essay

Spanish immigrantion to United States from 1800's to the 1865 - Essay Example The aim of this paper is to analyze the Spanish immigration from 1800 to 1865 in the lights of broad and diverse academic resources. Furthermore, it will analyze the impact of Spanish immigration on the economics of United States. As mentioned earlier, United States of America was the land of opportunities for the Spanish immigrants. The main aim of the Spanish immigrants was to find jobs in order to improve their living conditions. In the eighteen century, Spanish speaking countries had weak markets with extremely low wages. Some of them were experiencing political and economic stability and did not have jobs. Thus, Spanish immigrants moved to United States. During that time, Spanish immigrants were in demand because they possessed â€Å"good work ethic and little political voice† (Bankston & Hidalgo, 45). The creation and introduction of the steam engine in the nineteenth century called for the need of labor in order to place and put the track. Therefore, Spanish immigrants were allowed to migrate to USA. The invention and adoption of railway transport changed the structure of the United States in the nineteenth century. It concentrated on creating working opportunities and therefore, United States became the hub for immigration. Large number of Spanish immigrants migrated to US because of better working conditions and better wages as compared to their country of origin (Alexander, 159). The Spanish immigration proved to be beneficial for US in terms of economics as Spanish labor was readily available. Throughout the 1800s, Spanish immigrants were employed in construction industries, steel industry, etc. The expansion of rail road business meant for railway tracks and soon, majority of the Spanish immigrants were employed as labors in placing railway tracks. They also entered the agricultural domain and continued to work in industries. Research suggests that from 1800 to

LEADERSHIP Essay Example | Topics and Well Written Essays - 1250 words - 1

LEADERSHIP - Essay Example The scenario is based on the situation where I, as a leader; having conflict with a nurse who does not want to be team player. Based on the scenario three different roles being stated above have been highlighted and discussed in a precise and logical manner. From the Observer’s Point of View Healthcare institutions require people driven by passion and compassion in order to serve the healthcare needs of people. In order to make them think like this, leadership plays an important and crucial role. Being operating as the leader in the healthcare center, it was my role to align sources and resources in a positive manner along with enhancing their capabilities and abilities to make them highly valuable in terms of rendering their services to the society and people. There were a number of people working in the healthcare center based in Los Angeles having different goals and objectives. The goals and objectives of the healthcare center was based on offering high quality healthcare services to the patients along with making them feel cared and better in every sense. The goals and objectives of the healthcare center were communicated to the employees working in the center. However, at times, there were some clashes in the personal and professional goals of employees working in the healthcare center. ... A number of administration related queries were going unheard affecting the functional and operational framework in a significant manner. Even other people in the administration department were observing her behaviour but did not say anything mainly because of his nature and behaviour. The situation became all the more annoying when the operational framework was getting severely affected. There frustrated patients adding to the woes of the healthcare center. The observation part was mainly based on offering chances to that person in order to learn from her mistakes. However, there were not any initiatives being taken by her showing her ill behaviour affecting the entire framework of the center. Based on the behaviour of that nurse, few others started to ignore their work and responsibilities considering the fact that I was not saying anything to the employees even though, their behaviour was not acceptable. The overall change in the behaviour of others along with the change in the be haviour of that nurse started affecting the entire organisational setup in a negative manner. Unprofessional approach started prevailing at the highest level and thus thwarting the overall prospect of the healthcare center growth and development. Within months, there were dissatisfied customers and irregular and unprofessional operational and functional activities that affected the overall growth of employees and the center. I later realised that being a leader, it is important to observe but it is also important to communicate based on the observations. Mere observations did not add any value to the employees and the healthcare center and thus was of no use. Moreover, it crippled the entire operational and functional framework in a negative manner

Land law Essay Example | Topics and Well Written Essays - 2000 words - 2

Land law - Essay Example The major factor that will be taken into consideration by the Courts is how the Covenant is drafted. In the case of Martin v David Wilson Homes ltd2, the use of the word â€Å"a† in the covenant denoted a greater deal of flexibility than the use of the word â€Å"one† in the case of Crest Nicholson v McAllister3, where the Covenant was deemed to be fully enforceable. In this case, the drafting of the Covenant is very clear that the property is not to be used to set up licensed premises such as a bar and will be strictly enforceable, especially because it is also registered, and therefore negate the young couple’s purpose in purchasing the property. If Maggie and Dave choose to ignore the restrictive covenant and continue with building a bar on the premises, it could be demolished, as was the case in Mortimer and Another v Bailey and Another4, a restrictive covenant was successfully enforced to demolish a building. However working in their favor is the recent case of Sugarman and Porter and Others5 where an existing restrictive covenant on a property was deemed to be valid only up to the period the land remained unsold. In order for a restrictive covenant to be enforceable against subsequent owners such as Maggie and Dave, the land benefiting from the Covenant must be identifiable, but in this case the neighboring land belongs to a brewery which is not likely to benefit from the restrictive covenant against a bar on the premises. It is not immediately clear who can press for enforcement of this restrictive covenant, which was the same issue raised in the case of Crest.6 Maggie and Dave can also invoke the provisions of Section 84 of the Land and property Act of 1925, under which the Lands Tribunal may modify or discharge a restrictive covenant on a freehold title where over 40 years have passed. An application can be made by the young couple on the grounds that the existing covenant is an obstruction on the reasonable use of the property which

Moral Sentiments Essay Example for Free

Moral Sentiments Essay Pursuit of wealth is a necessity for a proper and well standard life in today’s world. Wealth is an essential commodity today and one has to have it for a respectable living and that is why people are in a run to achieve it not matter the opportunity cost. The main question is that is money always worth all the opportunity cost and is its achievement at all cost a right or wrong thing? These are the basic points that I will be discussing in my paper below with respect to my opinion of the poor man’s son situation, as described by Smith in The Theory of Moral Sentiments, that he was not mistaken in setting out on the path of wealth acquisition and further on I would discuss what I would have done if I was in the same situation. . There is no doubt to the fact that wealth is necessary for a comfortable living. Wealth improves the quality of life by providing a person with the luxuries he carves for and with the satisfaction of these cravings comes utility which in result makes a person feel good. There is more to life than living in a budgeted amount every month and feeling content with whatever is within ones limited achieving power. Life is about exploring new horizons, about enjoying it to its fullest and in today’s world all of this cannot be achieved without money. It provides a person with a sense of peace because with money comes power to achieve every material thing possible. Lack of money do not makes one life hassle free or tranquil but instead provides one with the tension to achieve even the basic necessities of life which now are not available without money. Hard work is necessary to achieve great things in life, laid back attitude do not take a person anywhere. High achievers do not let fate decide for them but work hard enough to have their fate in their own hand so pressuring oneself to achieve more in life and test one limits is actually the correct way to life live as per me. While it cannot be denied that more utility comes from enjoying the beauty of a garden then seeing a machine work as Smith explained in The Theory of Moral Sentiments, but it can also not be ignored that with the power to buy or have things one need which comes with the expenditure of money also provides a different sense of utility to a person. So I don’t think that the poor man’s son did anything wrong in working hard to fulfill his wants and dreams and instead of being critical of him one should appreciated him for fulfilling his dreams in the right manner, he at least did not cheat or lie his way to achieve what he wanted. I would have done the same had I been in his position. I would have also worked my way to achieve money if I had wanted it. But I would not have done that at the expense of that happiness in life which comes naturally along the way and have nothing to do with the amount of money one possess like enjoying a friend birthday treat, having time to enjoy the beautiful scenic beauty around me etc. I would have maintained the level of balance in my life with my priorities set in a proper order and money would be one of my priorities but not the top most priority. So I support the poor man son’s in his struggle to achieve what he wanted to achieve and his hard work is commendable but I think that he should have made money the only motive of his life and instead had enjoyed things coming in his life along the way because thirst for money can never be quenched so one should know the limit to have it if one want a peaceful n emotionally n spiritually better life. Reference: Smith, Adam. The Theory of Moral Sentiments. N. p. : n. p. , 1759. Print.

The Analysis Of The Crimson Shadow

The Analysis Of The Crimson Shadow The Crimson Shadow, by Walter Mosley, is a short story that depicts a lengthy morning encounter between two disparate, yet similar souls. It is a twining of events that connect and capture, evade, and then reunite under the bonds of commonality. The protagonist, an aging ex-convict who goes by the name Socrates, finds that a young man, a boy, really, has killed a rooster that resides across the alley, and someone he had considered his friend. Darryl, the boy who has committed the misdeed is an obvious product of his environment, struggling to survive the mean streets of Los Angeles, and who, at a very tender age, has also become its victim. The elements which make up this story are striking, and develop rapidly into a tightly woven interlude which allows the analysis of New Criticism to be utilized well, enabling an investigation which clarifies the components that help to create this piece. Both characters depict a sense of loss and tragedy, but also possess a keen intellect which helps them to overcome the depravity of their surroundings. When Socrates first realizes that Billy, the rooster to whom he had become attached-his crowing that had awakened him each morning for the past eight years has not been heard-he investigates by going out to where the bird lives, only to find that his head has been badly mangled by the serrated blade of a steak knife. When he sees Darryl move out of the shadows of the morning, he understands immediately that some wrong has been committed. The old man is, at first, justifiably angry at the fact that a senseless act of violence has been done, a crime committed by a troublemaking kid out to cash in on someone elses misfortune the boy has created; but the two have a shared past that connects them in more ways than either can initially appreciate. As the morning wears on, and Socrates gets to know the boy and his situation a bit better, the ex-con sees that the youngster and he have more in common than he would, possibly, like to admit. When Socrates gets the boy into his kitchen, and the two begin to talk, the elder sees how similar their situations are. Both have committed heinous crimes, that of murder, and he uses the time to try and reason with the boy as to the path hes headed toward, first, enticing him to open up when the man realizes his accusations of having killed his friend have the boy visibly nervous, and then understanding that its not only the rooster he has killed, but also another mentally challenged young man who wouldnt leave him and his friends alone. Although it was an accident, and Socrates tells him so, the older man sympathizes with Darryl, telling him that he is welcome in his home whenever he likes, this, an indication of his compassion, and perhaps of his empathy, with the boy. The setting of Crimson Shadow is marked by crushing poverty, the description of what is Socrates home scarred by time and neglect. Its depiction and its imagery are stark, as witnessed by the cabinets that are now simply shelves, the doors having been torn off, and the magenta tiles that have faded to grey. A red spider spins her web above a naked bulb that shines above a photo of a woman Socrates once knew. The use of sharp and focused vocabulary that prime colors and distinctive smells evoke is also prevalent and speaks of a harsh reality. When the boy enters the two room shack, he looks at the red spider, and the women in the picture who also wears a red hat and a red dress, which, as the sun shines down upon her, throws a similarly red, or crimson, shadow across her face, indicating heat, or maybe wrath at the wrong committed by Socrates. The picture also contains the primary colors of yellow and blue, as well, those of the sun and the sky, which can similarly indicate the simpli city of how these two must survive: only with the mixing of other elements can the blending and shading of emancipation occur. When the old man begins cooking the equally-aged rooster, the well-defined description of the ingredients used, tomatoes, basil, and garlic, each possess their own and equally pronounced hue and aroma, a luxury that both men revel in and that can help to begin to express a possible solution to their bleak existence. The tension is tightly woven into the Crimson Shadow, especially in the beginning, when Socrates confronts his much younger and much weaker opponent in the alley. His big hands, known as rock breakers, are seen as weapons, able to crush the young boy with a single blow, and his apparent time spent in prison is evidence enough that he is a disreputable man capable of both creating and enduring great harm. The story is immediately suspenseful when he realizes his friend, Billy the rooster, has been killed, but because he is an ex-convict who quickly acquires the position of a moral and upstanding citizen, a man who is eventually looked upon, ironically, as a role model, he is the protagonist, and as such, can be considered an anti-hero. This irony and its resulting paradox are, however, resolved in the end, when both boy and man agree, silently, to become friends in this hostile world they must both inhabit. The killing of the innocent rooster, as well as of the innocent young boy who would not leave Darryl and his friend alone, are both necessary catalysts for both Socrates and Darryl, for if the two are to survive at all, they need each other in an essential, yet obscure manner, a mirror in which Darryl is able to see himself, yet set himself apart from the man that Socrates has become. The name, too, that Socrates owns, is but a taunting mockery that he must live with, ever knowing, but forever damned. It is also essential for one to observe the discussion Socrates initiates when speaking to the young man, for this is indicative of a common theme seen throughout literature; that of the wizened elder, competent and worldly, offering advice to the younger, less experienced, and woeful Darryl. His advice, although unwanted and disregarded at first, is deemed highly authoritative and even indispensable later, when Darryl finds himself floundering at the mercy of his actions, a child in the hands of fate, ignorant and vulnerable. He decides that since Socrates might just well have power over his destiny, he might have power over his own. In the end, the utilization of the New Criticism theory in the analysis of the Crimson Shadow, by Walter Mosley, is quite effective in understanding the elements used in the creation of this work. Characterization, setting, imagery, theme, and dialog, all come together in unison to produce an effective tool in the dissection and ultimate recovery of this short story, especially taken individually, which allows the reader to view through a lucid and comprehensible lens, a work of innate truth and redemption.

Treatment Options in Recurrent GBM Research

Treatment Options in Recurrent GBM Research Strategies for clinical applications The multi-omics data may also reveal important leads for therapeutic applications. A very recent review on GBM, reported outcomes of clinical trials investigating current treatment options in recurrent GBM, including anti-angiogenic, signaling pathway blockade and immunotherapy based approaches (1). However the genetic and cellular heterogeneity reflects in the modest results obtained so far. This necessitates identification and validation of better therapeutic targets and active strategies to combat GBM. Some novel strategies are showing promise in Phase II trials and preliminary data is becoming available, such as, EGFRvIII peptide vaccine, Rindopepimut; CD95 targeted monoclonal antibody, APG100 and multi-targeted tyrosine kinase inhibitor cabozantinib (1). A multi-pronged approach targeting a panel of proteins may thus hold the key to eliciting a synergistic response and prove more beneficial than current treatment modalities targeting individual markers. When it comes to circulat ory or plasma-based biomarkers, in view of the technical limitations encountered in deep and direct plasma analysis as discussed earlier, alternate methods which would allow prediction of tumor related molecules and their targeted exploration would be highly useful. One of the outcomes of the study was the identification of effective strategies for data analysis and integration, facilitated by the bioinformatics tools available today. It shows experimental identification of proteins passed through the screen to ensure analytical rigor and functional relevance as above (Stage 1). Biologically important and potential tumor specific proteins identified in expression studies are then assessed for their secretory potential based on computational prediction algorithms for signal peptide and transmembrane domain containing proteins, such as, SignalP and TMHMM, respectively and via non-classical secretory mechanisms using SecretomeP. These proteins are further prioritized based on their de tectability and occurrence in proteomic data for secretome, CSF and plasma analysis (normal or patient) (Stage 2). The potential secretory candidates are then explored in plasma in a targeted manner (Stage 3). Interestingly, some of these proteins were identified in analysis of plasma or CSF from GBM patients (2, 3). Once bioinformatically scrutinized as above and compiled, the candidate biomarker panels, can be subjected to validation and experimentation in cohorts of tissue sections, blood plasma/serum specimens from patients (Stage 4). We believe construction of such high confidence protein panels would be a valuable paradigm for studies in larger cohorts in clinical experimental designs. High confident lead candidates for experimental application GBM Secreted proteins Secreted proteins have an integral role in GBM tumorigenesis through cell growth, migration, invasion, and angiogenesis besides being important in normal physiological processes and thus instrumental to the discovery of cancer biomarkers. Besides being useful as markers for typing the tumor, their presence in easily accessible body fluids makes them useful for monitoring the disease progression or treatment response and recurrence. A thorough survey of all available literature was done to identify the several candidate biomarkers have been reported in serum or plasma of GBM patients and these are shown in Table 1 in Chapter 1. However, such potential and promising new biomarkers are yet to be rigorously evaluated for application against this unmet need. Non-invasive methods based on circulatory biomarkers would be useful for monitoring not only GBM patients but also for lower grades Grade II and III tumors that exhibit longer survival periods. Further, some new reports on circulating tumor DNA (ctDNA) that have identified in the plasma of GBM patients such as mutated IDH1 DNA (4), methylated MGMT DNA (5) and EGFRvIII mutant DNA (6). The highly sensitive sequencing based methods for detection of circulatory tumor DNA (ctDNA) in patients plasma are under progress (7). These ctDNA markers shed by dead tumor cells may surface in future to be reasonable indicators for tumor diagnostics. Kinases in GBM Identification of GnRH signaling pathway using an alternate approach As mentioned in Chapter 2, I used alternate approaches to enhance pathway views by targeting specific protein families, i.e. kinases. Protein kinases (PKs) are well known therapeutic targets in different cancers and a family of proteins that are major components of signal transduction pathways acting as membrane receptors (RTKs) or as intracellular signaling mediators (non-receptor PKs) and several protein kinases have been implicated in gliomagenesis (8, 9). Several studies have also shown altered expression of protein kinases in GBM and targeted therapies directed towards RTKs using kinase inhibitors are in clinical trials (10, 11). There is renewed optimism in the use of kinase inhibitors to treat GBM (12). New therapeutic strategies have emerged that use multi-targeted kinase inhibitors to simultaneously disrupt multiple kinases (13). The GBM data was found to be enriched with several kinases. A total of 102 kinases were present in GBM datasets; 77 different kinases in transcript omics data and 30 kinases in proteomics data with 26 in common between them.   Pathway analysis using these kinases revealed GnRH signaling as the top pathway that has still not investigated in the context of GBM. We observe an overall enrichment of about 129 entities from omics datasets of which 26 kinases and 57 non-kinase members are coming from the concordant (n=711) transcriptome and proteome dataset. The 26 concordant kinases along with their fold changes are shown in the Figure 48 below. A large proportion of GnRH pathway entities include kinases (MAPKs, CAMKs, and RTKs) that enabled its identification as a top pathway using this approach. A targeted search of other non-kinase members of the pathway resulted in additional members of the pathway in omics datasets that further increased its significance value. In GBM, it has been shown that human GnRH receptors are expressed in tumor cells and receptor activation affects apoptosis, adhesion and angiogenesis to promote tumorigenesis. GnRH signalling as a possible therapeutic target in cancer has already been suggested and put together with my observations it strongly supports this possibility in the context of GBM. The expanded hand-curated map of GnRH signaling is a valuable resource for the scientific community. Expression of GnRH and GnRH receptor has been reported in GBM cell lines and tissue samples at both mRNA and protein levels concordant with clinical data obtained using GBM tumor tissues and treatment with GnRH agonists resulted in anti-proliferative activity (14-16).There is also evidence that the analogues can cross the blood-brain barrier, indicating suitability for treatment of malignant glioblastomas (17). Given the significance of this pathway in cancers and GBM, further understanding the molecular interplay involving GnRH signalling pathway in light of my findings will reveal is use as a potential molecular and therapeutic target.      Ã‚   Glioma Amplicon and Risk Regions The protein coding genes implicated in Glioma and other cancers were clustered based on their chromosomal locations using Gene Set Enrichment Analysis tools to compute overlaps with positional gene sets from Molecular Signatures database and further clustered based on proximity to other known oncogenes from Atlas of Genetics and Cytogenetics in Oncology and Haematology data resource, to identify colocalized gene clusters on Chr. 12 and other chromosomes as shown in Chapter 3. An important finding was that larger number of overexpressed differential regulated genes in glioma datasets mapped to two significant regions the glioma amplicon (n=37) in 12q13-15 region and the glioma susceptibility (n=16) in the 12p13 region implicated as a major risk region in patients with a family history of gliomas. The discovery of these two clusters of overexpressed genes provides a biological validation of mass-spectrometry derived data. Apart from these two essential regions, several genes from the glioma dataset were found to cluster around amplicons on other chromosomes and other known cancer associated genes that were not identified in GBM datasets but present in close proximity to them. These can be investigated in a more targeted manner in glioma.   Many studies have been done to understand the biological significance of these amplicon regions in gliomas that indicate that these amplifications are more frequent in gliomas than previously thought and have different distribution patterns in low grade versus high grade tumors (18, 19). Overall, a relative high degree of amplifications and deletions are seen in GBM that have implications on the expression of the genes involved and contribute to relevant pathogenic genes (20). Novel genes and isoforms Alternative splicing increases the repertoire of protein functionality and heterogeneity and aberrant splicing events have been frequently seen in several cancers, including GBM and increasing evidence now points to their important role in tumor initiation and progression. The concept of proteogenomics has emerged rapidly as a valuable approach to integrate mass spectrometry (MS)-derived proteomic data with transcriptomic data to identify novel splice variants. However, the role of alternative splicing in GBM is still nascent and needs to be explored as potential biomarkers or molecular targets. As detailed in Chapter 4, the identification of a novel variant of NCAM1, using a proteogenomics approach with 5 peptide evidences from MS data spanning a novel exonic region, is very significant finding in GBM. NCAMs are well characterized glycoproteins that mediate cell-cell or cell-matrix adhesion among neurons and between neurons and muscle. Several splice variants of NCAM1 have been identified (21, 22) and alterations in these have been found in serum and tissues of brain tumors (23, 24). NCAM1 has 5 known isoforms and also exhibits glycoforms as it can be post-translationally modified by the addition of polysialic acid (PSA), which is thought to abrogate its homophilic binding properties and affect the adhesive properties of NCAM (25). Further, PSA conjugated NCAM, was shown to potentiate migration via FGFR signaling distinct from its adhesion capability (26).   The following observations may be noted with respect to this novel variant: The observation is supported in transcriptomics data in 18 out of 25 RNAseq samples. Multiple gene modelling software such as Augustus, GenScan, AceView and Ensemble support the presence of this novel exon in their gene models and a high degree of conservation was seen as expected for an exonic region. This variant was also separately identified in MS-derived Human Proteome and IvyGAP RNAseq datasets NCAM1 is upregulated in several cancers; however, in GBM both transcript and protein data support its down regulation.   We observed two known forms of NCAM1 as well as the novel form to be down regulated. It is interesting to note that the miRNA (hsa-mir-30a-5p) that regulates NCAM1 is upregulated in GBM indicating the deregulation of a putative oncogenic cascade. In summary, our findings demonstrate the usefulness of combining omics approaches to identify novel putative candidates in GBM. Although, it is not clear if the novel splice variant represents a major or minor form of NCAM1. At the transcript level, it seems to be a minor component; however, preliminary assessment at the protein level is suggestive of it being a predominant form. Regardless, it would be interesting to explore the biological significance of the novel splice variant of NCAM1 and examine its role in GBM tumorigenesis. Hence, in the light of this observation my identification of novel NCAM1 splice variant through proteogenomics analysis using GBM RNAseq data is a very important finding in GBM. The effect of this novel variant on cell-cell adhesion and migration in GBM needs to be further investigated in a targeted manner. Disease implications and targeted analysis Studies suggest that gliomas constitute a rapidly progressing neurodegenerative disease caused by the malignant growth of glial cells that nourish neurons, resulting in a loss of brain function. Glutamate excitotoxicity is observed in several neurological diseases, which is also utilized by gliomas to gain growth advantage (27). My observations that neurological conditions like Alzhiemers and Parkinsons disease share many common genes with gliomas possible indicate shared molecular mechanisms inducing neurodegeneration. Further, the chromosomal mapping of glioma differentials revealed two clusters; one around 12p13 implicated as a glioma risk region and another around 12q13-15 region harboring a glioma amplicon with several overexpressed and amplified genes. Hence, extracting gene/disease associations and generation of a glioma-centric functional and diseasome network is important for understanding GBM tumorigenesis. Further, this region was found to be enriched in several cancers in cluding other brain neoplasms and neurological diseases that may share disease genes and processes with gliomas. Only 22 of the observed 108 disease genes in the diseasome network were identified in our proteomic analysis. The other 86 disease genes implicated in gliomas but not identified in our dataset can be investigated in a more targeted manner in gliomas, providing a global view of linkages between disease phenotypes. Additionally, the finding that chromosomal proximity of genes may have an impact on their functions can be used to explore the functions of missing proteins mapping within functional cassettes of related protein/genes. Such investigations offer newer paradigms that may be valuable to investigate and present clinically important targets. Future Scope Metabolomic data integration and potential Compared to the genome and proteome, metabolome represents the phenotypic changes more closely and has already been investigated for malignancies such as breast, ovarian, colon, prostrate and esophageal cancers. This line of investigation has been extended to gliomas albeit on a smaller scale, revealing novel insights into the role of metabolites in GBM tumorigenesis (reviewed in ref. (28)). Previous studies have revealed how mutations can lead to generation of oncometabolites such as 2-hydroxyglutarate (2-HG) specifically in IDH1 mutated gliomas (29). The discovery by Otto Warburg that cancer cells prefer to metabolize glucose through a seemingly inefficient process of aerobic glycolysis   led to the application of 18-FDG-PET imaging to predict the histological grade of gliomas.   Using this technique we could now distinguish low grade gliomas that have low specific uptake (SUV) values from grade III and IV that have higher SUVs.   One study performed global metabolic profilin g using mass-spectrometry coupled to liquid/gas chromatography on patient derived tumor samples and found increased levels of glutathione, tryptophan and metabolites associated with phentose phosphate and nucleotide synthesis and glycolytic intermediates such as phosphoenolpyruvate (PEP) and 3-phosphoglycerate (30). These studies have collectively provided a window of opportunity for further investigation and integrating these changes with the changes at proteomic, transcriptomic and genomic levels will be the next big step in to study the underlying biology of these tumors. Improving pathway analysis with phosphoproteomics data Protein phosphorylation plays a central role in transmitting the signal from outside the cell through a cascade effect into an intracellular signal to control the biochemical pathways in all living cells. This mechanism of activation or deactivation can be orchestrated by protein kinases via phosphorylation and phosphatases via dephosphorylation. Modifications to these signaling networks via mutations or abnormal protein expression or post-translational modifications may underlie both development and progression of tumorigenesis. Glioma Repository In order to facilitate annotation of key terms and manage the collection of high-throughput data coming from different omics technologies and platforms and make it easier to store and retrieve large amounts of information, I proposed to a schema for data annotation, collection and deposition. The data will be stored in the backend, in separate tables in a relational database (RDBMS), to enable effortless retrieval of key information for particular candidates of interest and also allow for complex querying. The outline for the schema is given below. Figure 49: Schema for development of a glioma repository

Thinking Aloud Essay -- Reading Education Learning Essays

Thinking Aloud Reading comprehension may be the most important skill for any student to acquire and is therefore an area of particular interest to educators. Without adequate comprehension skills, students are limited in their reading, analytical and occupational abilities. To many, including the student’s themselves, comprehension or â€Å"good reading† skills begin and end with simple decoding. It is thought that if students can ‘read’ and define the vocabulary they are reading, then they also comprehend what is read. True comprehension goes far beyond decoding, however. True comprehension requires visualization of a text, predicting events in the text, making inferences about the text and clarifying what is not understood about the text in order to lead to higher level thought processes such as personally connecting with the text. Reluctant, beginning or low-skilled readers often do not have the ability to visualize, predict, inference or clarify what they are reading and so they do not truly comprehend what the text is or what it means. Too often, these readers do not understand that â€Å"good readers† go through a series of mental processes in order to comprehend the text in ways which the low-level readers never even imagined. As educators, it is our job to show reluctant, beginning or low-skilled readers what these processes are and how they work in an attempt to boost the self-confidence and independence of these readers. One excellent way to set about this is through a strategy called a â€Å"Think Aloud†. The â€Å"Think Aloud† strategy is a teaching strategy which goes beyond teacher lecturing and is actually an exchange between teacher and student. First, the teacher demonstrates and encourages t... ...pecially designed to help dependent, beginning or low-level readers to see and understand exactly what it is that â€Å"good readers† do. Showing them this breaks down barriers which the students have built up against reading and comprehension. Most of all, the Think- Aloud is a more than sufficient method for giving students the skills they need to succeed in any reading situation they may encounter, whether it be in Social Studies class or the all important, ever watchful, standardized test. Works Cited Beers, Kylene. When Kids Can’t Read: What Teachers Can Do. Portsmouth, New Hampshire: Heinemann, 2003. Oster, Leslie. â€Å"Using the Think-Aloud for Reading Instruction.† The Reading Teacher 55 (September 2001): 64- 9. Wilhelm, Jeffrey D. â€Å"Think Alouds Boost Reading Comprehension.† Instructor 111 (2001): 26-8.

Argumentive Essay Against Euthanasia -- essays research papers

Euthanasia The mind is a terrible thing to waste, stated by anti-drug commercials. We all will either appreciate or underrate our life based on certain experiences we live through. Many go through dramatic experiences that make life uncomfortable or more strenuous than surrounding patrons do. Religious beliefs often affect the reasoning of decisions and the importance of life. Some people live in a vegetable status since their body is still performing, but their mind is not. The government will not allow their death since it is unconstitutional and deemed as murder. Euthanasia ends a life and is exercised regularly overseas. The immoral act of euthanasia defies humanity and the purpose of life. Some feel euthanasia needs legalization throughout the United States for vegetable patients. Currently Oregon allows physician-assisted suicides if certain medical conditions are present. The Pope John Paul II stated ?A man, even if seriously sick or prevented in the exercise of its higher functions, is and will be always a man ... [he] will never become a 'vegetable' or an 'anim...

Underlying Trend Rate of Growth

Explain the term ‘underlying trend rate of growth’ and the factors determining this rate. The underlying trend rate of growth represents a curve which shows the annual potential growth maximum that can be achieved with all available resources. An economy must target to increase this rate of growth and also actualize it. If the economy grows higher than this rate it will experience inflation. If lower it still has the capacity to grow. The trend rate of growth for an economy also represents the aggregate supply in the long run. The production possibility frontier also represents virtually more or less the same thing.There are various factors that determine long run aggregate supply. One considerable factor is the level of investment in an economy. Investment is vital as it is the back bone of economy. It enhances an economy by building more facilities and providing infrastructure to further develop and produce more, both in terms of quality and quantity. The higher the le vel of investment the higher the increase in capacity terms what an economy is able to produce. This is the growth that is in the nation’s stock of capital. New capital embodies technological advancements which leads to higher levels of productivity.The trend rate of growth is also determined by the trend growth of the working population of an economy. This is the trend of supply in the labour market. When the size of the working population increases it increases the potential working capacity of the economy. The magnitude of change in production output will reflect upon the level of labour/capital intensiveness in the economy. If the government can successfully increase the number of people of working age the trend rate of growth will increase. The trend rate of growth of factor productivity is a measure of gains in factor efficiency.For most countries it is the annual rate of growth of productivity that drives the long-term rate of economic growth. But of more interest and importance is where gains in productivity come from. The macroeconomic data on productivity is simply the aggregation of productivity performance at a microeconomic level throughout every industry and market in the economy. Technological improvements which reduce the real costs of supplying goods and services and which lead to an outward shift in a country’s production possibility frontier

International Bus Essay

1. Who are the various stakeholders that Anglo American needs to consider as it adopts an effective HIV/AIDS strategy? The people are said to be the driving forces of a country’s economy. In South Africa, AIDS has greatly impacted the nation’s economy. As evidence, it was stated that from 1992 to 2002, the economy of South Africa lost over $7 billion annually which is approximately 2% of the country’s GDP. This is because of the death of workers with AIDS. As AIDS continue to spread, it will continue to bring down the per capita growth of South Africa by 1 to 2% every year. Being a mining conglomerate, Anglo American operates in 45 nations and has over 107,000 employees. As Anglo American adopts an effective HIV/AIDS strategy, it should considering gathering as stakeholders all nations that are greatly reliant on the goods produced by the African workers. Anglo American must also consider health organizations, South African government, and big companies. It is im perative for the people in power to realize the impact of AIDS to the South African economy. 2. What are the pros and cons of Anglo American’s adoption of an aggressive strategy in combating HIV/AIDS among its South African workforce? What recommendations would you give the company concerning its HIV/AIDS policy? Since Anglo American was greatly hit during the outbreak of AIDS, the company developed comprehensive and dynamic approaches to combat the disease as it has become very ravaging to the workforce and its operations. The program was made up of prevention initiatives with focus on education and awareness. The program also included dissemination of condoms, financial as well as skill-related training to lessen poverty, and a survey system that would monitor the pervasiveness of the disease. Later on, the policies were expanded and included counseling, testing, as well as care and wellness programs. Some of the pros of the program include decrease payment for the patient as the number of people participating in the program increases. Despite the benefits of this aggressive strategy, there were many cons to this including the disapproval from many other interested parties. The program has also been unsuccessful because of refusal of some employees to undergo ART. Some even stopped during the treatment regimen. Other workers did not try submitting to the program because of fear of discrimination while others were in denial of having been contacted with AIDS. A robust approach is essential in this matter. If discrimination is an issue for workers, then as much as possible, the company should adopt a program that will respect the privacy and confidentiality of the patient’s condition. In addition, since some patients are anxious about the cost of the treatment, the company must consider encouraging more stakeholders to support the program and deliver the treatment for free. 3. Because such a large percentage of its workforce consists of migrant workers who are more likely to acquire and spread HIV/AIDS, should Anglo American adopt the policy of not hiring migrant workers? Should the South African government close the doors to migrant workers? Closing the doors to migrant workers would be another case of discrimination. Since the majority of the company’s employees are migrant workers, the company must consider proper screening before hiring. In hiring employees, companies must make sure that the people are in good condition and are ready for work. A physical check-up must be required. Migrant workers should not be stopped from working in Anglo-American provided that they meet the criterion of being HIV/AIDS-free. 4. What role do pharmaceutical companies play in responding to the HIV/AIDS epidemic in South Africa? What policies or courses of action would you recommend to a company that produces HIV/AIDS drugs? Pharmaceutical companies are the ones responsible in manufacturing drugs needed for the treatment of HIV/AIDS. GSK for instance, deliver drugs to South Africa. However, Anglo American is hoping that pharmaceutical companies would reduce their prices to be able to provide more drugs for the people infected with HIV/AIDS. Though pharmaceutical companies wish to  reduce their prices, they are also somehow hesitant in fear of violating the intellectual property rights. Policies or courses of action to consider to a company that produces HIV/AIDS drugs would be to lift up the intellectual property rights of drugs in nations such as South Africa which is in dire need of treatment.

Broadband Methods

There are several broadband methods that can be used to provide high speed internet access at home. The selection of the method is determined by the requirements, the availability of the hardware which is determined by the location of the user and the installation cost. Some of the most common methods include digital subscribers line (DSL), cable internet and satellite internet among others (Lemke, 2001). Due to its availability and speed relative to other options, I would prefer satellite internet for home use. Digital subscriber line is the most common home internet access method and provides network over the telephone lines.The main advantages of DSL that the subscriber is always connected, the hardware can have multiple uses (it is used as a phone and as an internet access devise at the same time), it provides a wide range of prices depending on the speed and a wide range of service providers. However, its use is limited by varying speed, availability, download limits and the spe cial equipments that must be installed by the telecom company. Cable internet on the other hand uses other coaxial cables other than telephone cables such as the television conduits. This broadband method has the basic advantage of being inexpensive and higher availability.On the other hand, it has the disadvantage of congestion and security problems associated with sharing of the network. Moreover, it is more suitable for multiple computers in home use (Steve Internet Guide, 2010). Satellite internet consists of a mini satellite disc mounted by a service provider. It has the advantage of always being connected and high speed. It is however more expensive compared to other options (Gustafson, 2005). Reference Gustafson, C. J. (2005). Disgusted With Dialup? – Compare DSL Providers, Cable and Satellite Internet to See If One Is Right for you, retrieved on July 9, 2010 from:http://www. buzzle. com/editorials/1-27-2006-87484. asp. Lemke, T. (2001). Cable, DSL or satellite? High-s peed internet connections can download information 50 times faster than a standard 56-kilobyte modem. But technology hasn't caught up with demand, retrieved on July 9, 2010 from: http://findarticles. com/p/articles/mi_m1571/is_47_17/ai_80900393/? tag=content;col1#comments Steve Internet Guide (2010). Broadband Internet Connection Methods, retrieved on July 9, 2010 from: http://www. steves-internet-guide. com/Broadband-Internet-Connections. php

Making a Wise Choice by Avoiding Early Marriage

He has his whole life ahead of him and he still has lots to learn and experience. . What qualities of a mature person does the author possess? -The author seems to possess the qualities of being a mature, wise and responsible Individual. These are evident In the decisions that he made based on morality and not on emotions. He learned from the experiences of his friends and made a realization that a mature person must not act on Impulse and every decision must be done with critical and reflective thinking. . What qualities of an Immature person do you find In his friends? -Considering the choices made by his friends regarding relationships, we think hat they are Immature In a way how they made decisions without weighing the consequences of their actions. Sure, they were ready to face the foreseen responsibilities of being a father but they were not mentally and financially prepared to create a family of their own. 4. Have you had any encounter with Incidents salary to those of the aut hor?Give a personal reaction to your observation In relation to getting married and having a family. -We haven't had such encounters salary to the author. However, we think that entering a relationship and getting married Is a fastidious decision that requires ore time and experience to learn from. It entails huge responsibility that must not be taken lightly. Not everyone Is destined or given the opportunity to have a family; some embrace the path of single blessedness while others are called to live a religious life.Making a Wise Choice by Avoiding Early Marriage By Karakas-Manual MANUAL, Karakas Pauline D. J. HOBBIES, Mane Crystal JOY L. Responsible individual. These are evident in the decisions that he made based on made a realization that a mature person must not act on impulse and every decision 3. What qualities of an immature person do you find in his friends? Hat they are immature in a way how they made decisions without weighing the 4. Have you had any encounter with incid ents similar to those of the author?Give a personal reaction to your observation in relation to getting married and having a -We haven't had such encounters similar to the author. However, we think that entering a relationship and getting married is a fastidious decision that requires more time and experience to learn from. It entails huge responsibility that must not be taken lightly. Not everyone is destined or given the opportunity to have a family; religious life.

Written Assignment - Displaying Leadership Example | Topics and Well Written Essays - 250 words

Written - Displaying Leadership - Assignment Example Because the behaviour was left to go too far, Paul found it normal to be loud with customers and even bully them into agreement. He went on to boast that he could win with any customer until the day he yelled at the mother to the head of Paediatrics. Consumers of healthcare include employer groups, patients, and agencies of government, family members and third party payers. Today’s consumer is sufficiently informed and empowered hence Paul’s behaviour couldn’t go far. Being left to continue would mean even new employees learns the same and clients continue suffering. The ultimate impact is a negative publicity of the hospital as one that does not have customer service standards. As a leader it is my responsibility to model good customer service not only in Paul but also the new employees. I would do so by making sure everyone understands the importance of organisational values; empower them with skills to offer quality customer service and emphasis on education and training. I will also stress the importance of accountability and transparency as well as adherence to set standards and procedures. Another important element of customer service is communication, feedback and measurement of compliance (Rabert, 2012). The goal is for every employee to understand the value of customer satisfaction. 1. Anne S. Rabert. (2012). Making the Transformation to a Customer-Service Orientation. American Nurse Today, 7(1). Available at:

Jazz music concert Essay Example | Topics and Well Written Essays - 500 words

Jazz music concert - Essay Example Jack Jones jazz band among others. As usual, the weekend of 27th June was no exceptional, Jack Jones band was competing with a new band in town called Ron Carter trio band. Both bands are led by Jack and Carter respectively. Jones performed some of his newly composed music jazz genre, and he tried convince the whole crowd why he wanted his band to be recognised the best band in jazz music. His music was well orchestrated and organised with most of the instrument tuned to their right tune, played in the right keys and rhythm. Indeed Jones band members tried to remain on the right keynotes always throughout the music play. However, there rose a problem when the saxophone player went off key, perhaps it was because of a change of song since it was a three-music nonstop competition.Ron Carter trio band, led by Carter, was as well on its right step to fight for their best position in the whole arena of jazz music. The team was similarly organised with all the instruments arranged in a wel l-choreographed manner to produce the best synchronised music. Their lead soloist was well prepared, and it seemed all went well for the band until some few minute to end when the lead guitar man played an off key note resulting to the presentation to halt for some few minutes to correct the mistake before restarting.In comparing both the presentation, I can start with analysing the first presentation of Jones.It was only interfered with the slight discord that was played by the saxophone player.

Strategic Management of Cooper Industries Case Study

Strategic Management of Cooper Industries - Case Study Example It is evidently clear from the discussion that Cooper Industries had always been aggressive in its diversification strategies as a means to add value to its manufacturing. While the period from 1967- 1970 was marked by the acquisition of related industries, Cooper industries grew from diversification by acquiring unrelated industries in the year 1980. Cooper Industries considered situations of crisis as opportunities and thus followed three basic principles while deciding upon acquisitions: the target company should be a market leader, the target company should be stable and has a good market for its offerings, the acquisition should make Cooper Industries a market leader in the respective industry. In its diversification regime, Cooper Industries had suffered both profits and losses. For instance, the acquisitions of hand tools, Gardner-Denver and Crouse-Hinds supplied diversification revenues while Dresser and Carrier and Black and Decker resulted in loss conditions. Thus, deciding upon the acquisition of Cameron Iron Works and Champion Spark Plugs is a dicey situation for it where it has to analyze its strengths, weakness and other factors which can provide efficiency without raising the debt burden. Over a period of thirty years, Cooper Industries acquired almost 60 manufacturing companies to add on to its manufacturing expertise. This not only made it independent of the external environmental pressures but also provided diversified revenue base where the sale of one segment compensated for another during tough times. Its organizational strategy was also aligned to the business strategy where every single acquisition was first closely analyzed and then acquired. Its MD&P (Management Development & Planning) division constantly worked on acquisitions to eliminate poor performing or redundant product lines and integrates the acquired business into its own. In these efforts, even relocation of acquired companies plants or reorganizing the staff made all the acq uired companies its profit centers. In order to gain a better understanding of its internal and external environment, the SWOT analysis puts the light.

North American Civilization Paper Essay Example | Topics and Well Written Essays - 750 words

North American Civilization Paper - Essay Example No attempts were made to immigrate to Antarctica so the migration essentially stopped there. The enormity of the landscape allowed two distinct sources of food delivery to evolve: maintenance of hunter-gatherer societies in nomadic formations and agricultural societies tying themselves to distinct geographical enclaves. The book contends the population to be 5-10 million but other sources place the number between 2-7 million. Agriculture increased the complexity of the societies that developed in the various areas of continent. Men tended to wield more power and influence in the hunter societies while the women of the tribes started to come into their own in the agricultural societies. The increased complexity of the societal fabric tended to bring more power to the women of the tribes. The relative scarcity of arable land or diminished animal populations for consumption tended to dictate the type of civilizations that would arise around the provision of foodstuffs. They tended to va ry in shape and complexity. While the Pueblos tended to an increasingly sophisticated agricultural society, the Iroquois all the way on the other side of the continent erected an equally sophisticated culture of their own. The availability of edible wildlife tended to dictate the societal formations that emerged. Davidson et al asserts that nearly 70 Pueblo villages flourished by 1540, a little more than a generation before the Gutierrez map was published. The variations in living and cultural differences between the tribes were as large as the continent was wide. A vast panoply of climates, topography and variations in water systems made a huge tapestry of different lifestyles and tribal constructs apparent. The division and sheer variety of tribal affiliations, lifestyles and resistance to unity made the aboriginal tribes in North America especially vulnerable to the depredations that would be visited on them in the coming decades and centuries. Internecine and centuries old triba l feuds and warfare made it almost impossible to prevent the European tidal wave that was coming. The authors make short shrift of the massive internecine conflict that had embroiled the continent for centuries between different tribes. â€Å"On the Western Plains, pre?Columbian warfare—before the introduction of horses and guns—pitted tribes against one another for control of territory and its resources, as well as for captives and honor. Indian forces marched on foot to attack rival tribes who sometimes resided in palisaded villages.† In the eastern woodlands, â€Å"mourning wars† would take place where tribes would fight each other. It is sad to say that the tribal rivalries were a serious impediment to offering a united front against the European invasion on its way. Soon enough, as the eighteenth century emerged more than two hundred years after Gutierrez’ map made its debut, a European march westward marking the ultimate destruction of the ab original tribes of America began to gain steam and the North American Indian tribes’

Successful FDI Essay Example | Topics and Well Written Essays - 1250 words

Successful FDI - Essay Example This paper addresses benefits and disadvantages of FDI to both home and host countries and presents a brief business plan for the company linking its foreign investment proposal and analyzes its future plans. E-Walky Plc: E- Shoe and Slippers Electronic shoes and slippers from E-Walky Plc will be extremely amazing experience to the new generation. In today’s technology-driven business environment and life-style, the company plans ‘e-walking’ of new generation. E-Walky, a public limited company headquartered in Colorado, is in its very progressive stage of developing new products, e-shoes and slippers. The days yet to come are to witness how the slippers and shoes can be integrated with advanced technology to make an easier life to both sportsmen and general public. Company plans to campaign its brand name ‘E-Walky’ for its products and chooses China for its FDI. It’s truly going to be a mere micro-computer in every one’s foots, being att ached to the down-part of slippers and shoes covered by specific metals for its safety as well as water-proof purposes. These micro-chips can automatically measure the distances one walks, counts his footsteps, measure the speed of a sportsman and so on. Count-down, safety-walk and speedy-walk are some extremely useful utilities that the company itself kept secret and rather surprising to the public. Its usefulness to electronically track one’s footsteps will attract indoor players of badminton and tennis as well as outdoor players of cricket and football. Its importance to play ‘two-men game’ and group games will certainly appeal to children and youngsters. Its importance to health and convenience to use inside houses will attract both house-wives and old aged customers. More specifically, all these customers will find its operation wonderful and convenient due to the small ‘remote controller’ in their hand. E-Walky Business Plan The main objective of E-Walky is to design and develop electronic shoes and slippers to its customers in and outside the US to continuously promote the digitized life for both general public and sportsmen. The main mission is to create a generation of ‘e-walking’ with help of the highly advanced technology the company adopted in developing E-Walky shoes and slippers. The financial management of the company proposed an initial investment of $10 million to establish the enterprise based in Colorado and to expand the business by directly investing in China with an approximate expenditure of $25 million. It plans to start its R&D and manufacturing activities in the US and to sell around 1.5 million shoes in the US markets within first 12 months. At the same, the company’s operation will be held in large scale in China to market around 10 million products through major countries like Japan, UK, India, Brazil etc. The management expects that once its marketing starts in the US, it will a ttract a large number of sportsmen and other people from around the world. As planned, the penetration pricing policy would be used as a competitive tool to merit the firm and build a long-term brand image for the company (Hirschey, 2009, p. 567). The financial department proposed that the company would be able to sell more than 13 million products worldwide returning an

Sex Education Essay Example | Topics and Well Written Essays - 1000 words - 1

Sex Education - Essay Example er elements might need to be taught in future sexual education courses, Grace pointed to the fact that it could be potentially beneficial to integrate students with an understanding of Planned Parenthood or means by which many government and/or state sponsored programs seek to speak to the unique needs of the individual student. Ultimately, Grace described the sexual education course that she took part in as a useful and formative part of her early development (Scholz, 2013). Moreover, she indicated that with regards to speaking with parents concerning sexual topics, the interviewee noted that they had a very open and honest dialogue concerning such matters that began as early as late middle school and/or early high school. Conversely, the second individual who is interviewed, Priscilla Yua, noted that her sexual education class left much to be desired. Ultimately, with regards to the first question posed to the interviewee, the respondent noted that the sexual education course never seemed to deal with the realistic situations in which the student may very well face within their sexual growth and development; instead, it focused upon the grotesque, abnormal, and obscene. She noted that this was likely done as a means of horrifying the student from even considering any type of sexual intercourse for fear that they too might be irrevocably harmed. Similarly, with regards to what she most disliked about the program, Priscilla noted that it was the adolescent and juvenile behavior of the participants the most to the way from the experience (Yua, 2013). Likewise, with regards to what level of improvements could be offered, Priscilla indicated that transitioning sexual education to high school might necessarily benefit the individual due to the fact that they could take the... This paper approves that the fact that since individuals develop and mature at different rates, it is seemingly preposterous to assume that they should be taught extraordinarily personal and intimate details concerning human sexual development as a time in which they are ultimately upon different emotional and mental maturity platforms. By the way, sexual education is currently evidenced within the system that each and every stakeholder is satisfied with the level and extent to which key issues concerning sexual development have been covered and/or presented. Sexual education is begun within the elementary school and continues in the various means up until high school. This essay amkes a conclusion that it was the understanding of this interviewer that there was a clear level of correlation between those interviewees that had not discussed sexual topics with their parents/had not received formal sexual training, and those respondents that spoke unfavorably concerning the existence of sexual education or the net benefit they received while in public school. Although it cannot be inferred that the two this level of correlation there exists a definitive realization based upon us, it should be understood that is very likely that sexual attitudes, first evidenced within the family, transcend into the classroom and directly affect the overall level and extent to which be participant can hope to gain value such discussions.